Retrieve Process for Execution (RPE) is a proposed IHE standard for collaborative workflow or collaborative process management involving three main actors: 1/ the manager of process definitions, 2/ the manager of runtime processes and 3/ the performer of process activities.  RPE started as Retrieve Protocol for Execution Profile a proposed automated mechanism for an Electronic Health Record (EHR) to retrieve a complex set of clinical research instructions (a study protocol) from a research sponsor's Electronic Data Capture (EDC) system and to execute these instructions within the EHR. 